Ingredient comparison

Acetyl Tetrapeptide-5 vs Palmitoyl Tripeptide-1: which one is right for your skin?

Same comparison whichever way you searched it: Palmitoyl Tripeptide-1 vs Acetyl Tetrapeptide-5.

Short answer: Honestly, either one works. Choose by your skin type and what your routine already has.

Chemical structure of Acetyl Tetrapeptide-5 (Acetyl Tetrapeptide-5)Acetyl Tetrapeptide-5Promising, not proven
Chemical structure of Palmitoyl Tripeptide-1 (Palmitoyl Tripeptide-1)Palmitoyl Tripeptide-1Decent support
6
Efficacy
6
2
Hydration
2
3
Barrier
3
3
Brightening
1
2
Acne
0
5
Anti-aging
6
Acetyl Tetrapeptide-5 versus Palmitoyl Tripeptide-1, compared
ComparedAcetyl Tetrapeptide-5Palmitoyl Tripeptide-1
PotencySimilarSimilar
Evidenceemerging evidencemoderate evidence
Irritation riskLowLow
Clogs poresLowLow
In pregnancyConsidered safeConsidered safe
On a labelusually effective at 0.5-2%usually effective at 0.0003-0.003%

So which should you pick?

Choose Palmitoyl Tripeptide-1 if

  • you want the pick with the most research behind it

The honest bottom line: Honestly, either one works. Choose by your skin type and what your routine already has.

No known clash between these two. If you want both, you can layer them; introduce one at a time.

Check these two in the tool →Or decode a whole product label →

From our dataNeither has to be the answer: 58 other ingredients in our glossary share a family with these two.

Acetyl Tetrapeptide-5 vs Palmitoyl Tripeptide-1, answered

Which is stronger, Acetyl Tetrapeptide-5 or Palmitoyl Tripeptide-1?

They are close in strength: Acetyl Tetrapeptide-5 and Palmitoyl Tripeptide-1 score similarly on efficacy. Choose by skin type rather than power.

Is Acetyl Tetrapeptide-5 or Palmitoyl Tripeptide-1 better for sensitive skin?

Both carry a similar irritation risk (low). Patch test either one before using it daily.

Can you use Acetyl Tetrapeptide-5 and Palmitoyl Tripeptide-1 together?

There is no known clash between them. You can layer them if you like, just introduce one at a time.

General guidance, not medical advice. Read the full pages on Acetyl Tetrapeptide-5 and Palmitoyl Tripeptide-1.