Ingredient glossary

Gluconolactone

INCI: Gluconolactone · Also: PHA

Solid and proven

A genuinely useful ingredient with real evidence behind it, not hype.

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What it does

  • exfoliation
  • hydration
  • barrier support

moderate evidenceComparative studies suggest PHAs like gluconolactone can provide anti-aging and smoothing benefits similar to AHAs with significantly less irritation, making them suitable for sensitive skin.

On a label: works best above 4%.

Who it's for, and who should skip it

Tends to suit

  • sensitive
  • dry
  • combo
  • rosacea prone

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow
  • pH-dependentIts effect depends on the product's pH

Plays well with

  • humectants
  • ceramides

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Educational information about a cosmetic ingredient, not medical advice.