Ingredient glossary

Papain

INCI: Papain · Also: Papaya Enzyme

Promising, not proven

Early signs are interesting, but the proof is not in yet. Worth watching, not worth a premium.

Does Papain clash with what you already use? Check it →

What it does

  • enzymatic exfoliation
  • keratolysis

weak evidenceEnzyme peel literature and cosmetic texts describe papain-based peels as providing modest smoothing and pigment benefits at low concentrations with fewer barrier changes than strong acids yet controlled comparative trials are sparse.

On a label: usually effective at 0.1-1%.

Who it's for, and who should skip it

Tends to suit

  • normal
  • oily
  • combo

Approach with care

  • very sensitive
  • rosacea
  • compromised barrier
  • papaya allergy
  • Clogs poresLow
  • Irritation riskModerate

Pregnancy: Check with your doctor before using during pregnancy or breastfeeding.

Plays well with

  • humectants
  • soothing agents

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Educational information about a cosmetic ingredient, not medical advice.