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Ingredient glossary

Matrixyl Synthe'6

What Matrixyl Synthe'6 does for your skin, who it suits, and what to watch for.

INCI: Palmitoyl Tripeptide-38 · Also: Matrixyl Synthe-6

Promising, not proven

In short: Matrixyl Synthe'6 delivers anti-aging support and texture, suits most skin types, and the evidence behind it is emerging.

What it does
Anti aging, texture
Best for
Most skin types
Evidence
Emerging
Does it clash with what you use? Check it →

Written by Maya FaourHow we score →

The molecule

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The Glow take

Nice to have, and nothing to overthink.

Matrixyl Synthe'6 plays a quiet supporting role, rounding out a formula rather than being the reason you buy it.

— Maya

What it does

  • anti aging
  • texture

emerging evidenceTwo placebo controlled trials, on twenty five and on thirty two women, report lifting of about thirteen percent and wrinkle volume down about twenty one percent. Both were run by Sederma and no independent replication has been published.

On a label: usually effective at 1-2%.

Who it's for, and who should skip it

Tends to suit

  • normal
  • combo
  • photoaged
  • mature

Approach with care

No specific group flagged to avoid it.

  • Clogs poresLow
  • Irritation riskLow

How it fits each skin type

  • DrySuits
  • CombinationSuits
  • OilySuits
  • SensitiveSuits

Often chosen for photoaged, mature.

Where it fits in your routine

WhenMorning or evening
Where in the orderAfter cleansing, before your moisturizer

Plays well with

  • other peptides
  • humectants

Matrixyl Synthe'6, answered

Is Matrixyl Synthe'6 safe during pregnancy?

Yes. Matrixyl Synthe'6 is considered safe to use during pregnancy and breastfeeding. As with anything, if you are unsure it is worth a quick word with your doctor or midwife.

Who should avoid Matrixyl Synthe'6?

No specific group is flagged to avoid Matrixyl Synthe'6. It is well tolerated by most skin. Still, introduce anything new one product at a time.

What concentration of Matrixyl Synthe'6 actually works?

Matrixyl Synthe'6 tends to do its job in the 1 to 2% range. Much lower and it is likely underdosed.

Compare Matrixyl Synthe'6 with

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Sources & how we reviewed this

Last reviewed August 2026. Educational information about a cosmetic ingredient, not medical advice.