Ingredient glossary

PDRN

INCI: Sodium DNA · Also: Polydeoxyribonucleotide

Solid and proven

A genuinely useful ingredient with real evidence behind it, not hype.

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What it does

  • repair
  • hydration
  • anti aging

strong evidenceA double blind randomized trial of intradermal polydeoxyribonucleotide injections showed significant gains in hydration elasticity and collagen density versus saline yet comparable evidence for topical use is sparse.

Who it's for, and who should skip it

Tends to suit

  • normal
  • dry
  • photoaged
  • compromised barrier

Approach with care

  • pregnancy
  • breastfeeding
  • fish allergy
  • Clogs poresLow
  • Irritation riskLow

Pregnancy: Check with your doctor before using during pregnancy or breastfeeding.

Plays well with

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Educational information about a cosmetic ingredient, not medical advice.