La Roche-Posay Effaclar Duo+ M

Moisturizer~€20typical, July 2026

Our read, in one look

Niacinamide is the reason to consider this moisturizer, with Salicylic acid (BHA) behind it.

The case for it

  • Niacinamide, strong evidence for the barrier
  • Salicylic acid (BHA), moderate evidence for oil and breakouts
  • No alcohol or parabens

Mind this

  • Sunscreen the next day, acids leave skin more sun-sensitive
  • Myristyl Myristate: rates high on the pore-clogging scale
  • Add it on its own for a week or two, so you know what your skin is answering to
Best for dry, dehydrated, oily, combo skinFind it on amazon.com
Maya's read

La Roche-Posay Effaclar Duo+ M is a moisturizer built around Glycerin, Niacinamide and Salicylic acid (BHA). It leans strongest on hydration, barrier repair, brightening / tone. Best suited to dry, dehydrated and oily skin. One caveat: very breakout-prone skin may find it too rich.

Skip it if your barrier is already sensitised or compromised: the acids can sting broken or over-exfoliated skin.

The formula, drawn

Every ingredient in label order, coloured by the job it does here.

28 of the 35 sit above the 1% line. The other 7, hatched, are each under 1%. Widths show the ORDER on the label and nothing else: the label never discloses amounts, so we never draw them.

  • Actives & signals
  • Hydrators
  • Texture & base
  • Preservation
  • Not in our library yet

What it delivers

Hydration10
Barrier repair9
Brightening / tone7
Oil-control & blemishes10
Anti-aging6

How it feels A smooth, silky lotion that spreads easily and leaves a soft, near-blurred finish. (estimated from the formula)

What's in it that matters

The molecule doing the workGlycerinHumectant · strong evidence

Classic humectant with strong evidence for improving skin hydration and supporting barrier when combined with emollients.

  • NiacinamideHero Activestrong evidence

    Multitasking vitamin that improves barrier, reduces redness, regulates oil, helps with pores and pigmentation with strong clinical support.

  • Salicylic acid (BHA)Hero Activemoderate evidence

    Oil-soluble exfoliant that penetrates pores to reduce blackheads and breakouts; can be drying or irritating if overused.

  • Zinc PCASupporting Activemoderate evidence

    Zinc salt of pyrrolidone carboxylic acid that reduces sebum and provides antimicrobial and anti inflammatory support with good tolerability.

  • IsohexadecaneEmollientmoderate evidence

    Lightweight, non-greasy emollient that improves slip and reduces greasiness in creams and sunscreens.

  • Capryloyl Salicylic AcidActive|Supporting Activemoderate evidence

    Lipophilic salicylic derivative that provides targeted keratolysis and pore clearing with gentler peels for pigment and fine lines than stronger AHAs.

How to use it

In the evening, and not every night: 2–3 times a week is plenty. Follow with a moisturiser, and wear sunscreen the next day.

Keep it away from

  • Retinoids (retinol, tretinoin)
  • Benzoyl peroxide
  • Other exfoliating acids the same night
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Where it acts

The same cross-section as our 500 dalton page, with this formula's actives on the layer each one works on. Depth is the anatomy's, never an ingredient's.

5 of this product's actives have a layer we can defend. 1 did not, so it is not on the diagram: no source and no honest derivation means no dot.

Sources for the sourced ones: Boo 2021: mechanistic basis for topical nicotinamide; Ebanks et al. 2009: mechanisms regulating skin pigmentation.

Against the average moisturizer

HydrationBarrier repairBrighteningOil-controlAnti-aging
This productMedian moisturizer (11 in catalogue)

It scores higher than the median moisturizer on brightening and oil control.

On hydration, barrier repair and anti-aging it is level with the median, so that is not what sets it apart.

A median, not an average: one unusual formula should not move the middle. The numbers are the same 0 to 10 reads the comparison pages use.

The full ingredients list, decoded

Every ingredient on the label, in the order it appears (highest amount first). We link the 18 our library knows, name what each one does, and flag anything that can irritate or clog. The rest we leave plain, nothing is hidden.

All 35 ingredients, decoded
  1. Aqua/Water/EauSolvent (base)
  2. GlycerinHumectant
  3. DimethiconeOcclusive
  4. Isocetyl Stearate
  5. mild irritant
  6. Isopropyl Lauroyl SarcosinateCleansing agent
  7. SilicaAbsorbent
  8. Ammonium Polyacryloyldimethyl Taurate
  9. Oryza Sativa Starch/Rice StarchTexture
  10. Punica Granatum Pericarp ExtractBotanical extract
  11. Potassium Cetyl PhosphatepH buffer
  12. Sorbitan OleateEmulsifier
  13. Zinc PCAZinc salt
  14. IsohexadecaneEmollient
  15. Sodium HydroxidePh adjuster
    mild irritant
  16. may clog pores
  17. 2-Oleamido-1,3-Octadecanediol
  18. Mannose
  19. Poloxamer 338
  20. PropanediolHumectant
  21. Hydroxyethoxyphenyl Butanone
  22. mild irritant
  23. Caprylyl GlycolPreservative booster
  24. Vitreoscilla FermentBotanical extract
  25. Citric AcidExfoliant
    mild irritant
  26. Trisodium Ethylenediamine DisuccinateChelator (stabiliser)
  27. Maltodextrin
  28. roughly the 1% lineThe rules only require descending order above 1%. From Xanthan Gum down, these 7 can be listed in any order the brand likes, so position stops telling you anything.
  29. Xanthan GumThickener
  30. Polysorbate 80Emulsifier
  31. mild irritant
  32. Piroctone Olamine
  33. can irritate
Copy the raw INCI list

Aqua/Water/Eau, Glycerin, Dimethicone, Isocetyl Stearate, Niacinamide, Isopropyl Lauroyl Sarcosinate, Silica, Ammonium Polyacryloyldimethyl Taurate, Oryza Sativa Starch/Rice Starch, Punica Granatum Pericarp Extract, Potassium Cetyl Phosphate, Sorbitan Oleate, Zinc PCA, Glyceryl Stearate SE, Isohexadecane, Sodium Hydroxide, Myristyl Myristate, 2-Oleamido-1,3-Octadecanediol, Mannose, Poloxamer 338, Propanediol, Hydroxyethoxyphenyl Butanone, Capryloyl Salicylic Acid, Caprylyl Glycol, Vitreoscilla Ferment, Citric Acid, Trisodium Ethylenediamine Disuccinate, Maltodextrin, Xanthan Gum, Pentylene Glycol, Polysorbate 80, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Salicylic Acid, Piroctone Olamine, Parfum/Fragrance

Read enough? Find it on amazon.com

We don't make or sell skincare of our own. So there's nothing here we're trying to push, just an honest read of whether this formula suits your skin.

Compare it with…

All 10 comparisons

Common questions

Is La Roche-Posay Effaclar Duo+ M good for dry skin?

By our read of the formula, it suits dry, dehydrated, oily skin. La Roche-Posay Effaclar Duo+ M is a moisturizer built around Glycerin, Niacinamide and Salicylic acid (BHA). It leans strongest on hydration, barrier repair, brightening / tone. Best suited to dry, dehydrated and oily skin. One caveat: very breakout-prone skin may find it too rich.

How do you use La Roche-Posay Effaclar Duo+ M?

In the evening, and not every night: 2–3 times a week is plenty. Follow with a moisturiser, and wear sunscreen the next day.

What are the key ingredients in La Roche-Posay Effaclar Duo+ M?

The actives that do the work are Glycerin, Niacinamide, Salicylic acid (BHA), Zinc PCA, Isohexadecane, Capryloyl Salicylic Acid. The rest of the list is texture, preservatives and emulsifiers that hold the formula together.

What the 3D scene shows

The scene shows La Roche-Posay Effaclar Duo+ M beside a cross-section of skin, with 4 of its ingredients drawn at the layer each one acts on and at one shared molecular scale: Capryloyl Salicylic Acid and Glycerin and Salicylic acid (BHA) in the stratum corneum, the dead outer layer where most skincare works; Niacinamide in the living epidermis, among the cells that are still dividing. Depths come from the same sourced layer data as the rest of this site, and any ingredient whose layer is not established is left out rather than guessed.

Chemical structure of Glycerin
Building the scene…

This is skin, in section.

The molecules floating inside it are from this bottle, each at the layer it works on, drawn to one true scale. Drag to turn, pinch or scroll to zoom, tap a molecule for its evidence.

Skin in section· molecules from this formula · one true scale
tap it to decode ↻
Effaclar Duo+ MLa Roche-Posay · Moisturizer · ~€20

Niacinamide is the reason to consider this moisturizer, with Salicylic acid (BHA) behind it.

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