Medik8 Crystal Retinal 6

Serum~€86typical, July 2026

Our read, in one look

Retinal is the reason to consider this serum, with THD Ascorbate behind it.

The case for it

  • Retinal, moderate evidence for lines and firmness
  • THD Ascorbate, moderate evidence for tone and pigment
  • No alcohol, silicones or parabens

Mind this

  • Avoid in pregnancy: Retinal
  • Evenings only, sunscreen the next morning
  • Add it on its own for a week or two, so you know what your skin is answering to
Best for dry, dehydrated, normal, oily skinFind it on amazon.com
Maya's read

Medik8 Crystal Retinal 6 is a serum built around Glycerin, Retinal and Squalane. It leans strongest on hydration, barrier repair, brightening / tone. Best suited to dry, dehydrated and normal skin. One caveat: it's best skipped during pregnancy.

Skip it if you're pregnant or breastfeeding: it contains retinal, best paused until after.

The formula, drawn

Every ingredient in label order, coloured by the job it does here.

15 of the 47 sit above the 1% line. The other 32, hatched, are each under 1%. Widths show the ORDER on the label and nothing else: the label never discloses amounts, so we never draw them.

  • Actives & signals
  • Hydrators
  • Texture & base
  • Preservation
  • Not in our library yet
  • Retinal sits at position 29 of 47

What it delivers

Hydration10
Barrier repair7
Brightening / tone8
Oil-control & blemishes4
Anti-aging9

How it feels A rich, cushiony cream that sinks in slowly. Comforting on dry skin, possibly too much for oily skin in summer. (estimated from the formula)

What's in it that matters

The molecule doing the workGlycerinHumectant · strong evidence

Classic humectant with strong evidence for improving skin hydration and supporting barrier when combined with emollients.

  • RetinalHero Activemoderate evidence

    Potent cosmetic retinoid that sits one step away from retinoic acid, often delivering faster results than retinol with a similar or slightly lower irritation profile.

  • SqualaneEmollientstrong evidence

    Stable, lightweight emollient that mimics skin’s natural lipids and supports barrier without heavy greasiness for most skin types.

  • Hyaluronic acidHumectantstrong evidence

    Water-binding molecule that increases hydration; works best under occlusive/emollient layers to reduce evaporation.

  • THD AscorbateActive|Supporting Activemoderate evidence

    Oil soluble vitamin C derivative that brightens skin and supports collagen with good tolerability but has fewer long term studies than pure ascorbic acid.

  • Caprylic/Capric TriglycerideEmollientstrong evidence

    Light emollient ester that improves slip and reduces transepidermal water loss; may be problematic for some fungal-acne-prone users.

How to use it

Night only. Start 2–3 nights a week and build up as your skin adjusts, and always wear sunscreen the next morning, because retinoids make skin more sun-sensitive.

Keep it away from

  • Exfoliating acids (AHA / BHA)
  • Benzoyl peroxide
  • Strong vitamin C (L-ascorbic acid)
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Where it acts

The same cross-section as our 500 dalton page, with this formula's actives on the layer each one works on. Depth is the anatomy's, never an ingredient's.

5 of this product's actives have a layer we can defend. 1 did not, so it is not on the diagram: no source and no honest derivation means no dot.

Sources for the sourced ones: Szymanski et al. 2020: retinoic acid and its derivatives in skin.

Against the average serum

HydrationBarrier repairBrighteningOil-controlAnti-aging
This productMedian serum (17 in catalogue)

It scores higher than the median serum on brightening and anti-aging.

On hydration, barrier repair and oil control it is level with the median, so that is not what sets it apart.

A median, not an average: one unusual formula should not move the middle. The numbers are the same 0 to 10 reads the comparison pages use.

The full ingredients list, decoded

Every ingredient on the label, in the order it appears (highest amount first). We link the 27 our library knows, name what each one does, and flag anything that can irritate or clog. The rest we leave plain, nothing is hidden.

All 47 ingredients, decoded
  1. Aqua (Water)Solvent (base)
  2. GlycerinHumectant
  3. IsododecaneEmollient
  4. PPG-12/SMDI Copolymer
  5. Titanium DioxideMineral (opacifier)
  6. Eclipta Prostrata ExtractBotanical extract
  7. SqualaneEmollient
  8. roughly the 1% lineThe rules only require descending order above 1%. From Phenoxyethanol down, these 32 can be listed in any order the brand likes, so position stops telling you anything.
  9. PhenoxyethanolPreservative
    mild irritant
  10. Melia Azadirachta Leaf ExtractBotanical extract
  11. Hydroxypropyl MethylcelluloseThickener
  12. Tetrahexyldecyl AscorbateVitamin c derivative
  13. Alumina
  14. Isostearic Acid
  15. LecithinEmulsifier
  16. Polyglyceryl-3 PolyricinoleateEmulsifier
  17. Polyhydroxystearic Acid
  18. Stearic Acid
  19. RetinalRetinoid
    pregnancy: avoidmild irritant
  20. Moringa Oleifera Seed OilPlant oil / butter (emollient)
  21. Sodium Polyaspartate
  22. Climbazole
  23. Daucus Carota Sativa (Carrot) Seed OilPlant oil / butter (emollient)
  24. EthylhexylglycerinPreservative booster
  25. 3-O-Ethyl Ascorbic AcidVitamin c derivative
    mild irritant
  26. Dipteryx Odorata (Tonka) Bean ExtractBotanical extract
  27. HydroxyacetophenonePreservative
  28. Polysorbate 60Emulsifier
  29. Vanilla Planifolia (Vanilla) Fruit ExtractBotanical extract
  30. Decylene Glycol
  31. 1,2-HexanediolPreservative booster
  32. BHTAntioxidant
    mild irritant
  33. CoumarinFragrance component

Worth knowing: Retinal sits below that line. It is in there, and the label does not tell you how much. That is not the same as saying it is too little to matter.

Copy the raw INCI list

Aqua (Water), Caprylic/Capric Triglyceride, Glycerin, Isododecane, Cetearyl Olivate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, PPG-12/SMDI Copolymer, Sorbitan Olivate, Tocopheryl Acetate, Titanium Dioxide, Eclipta Prostrata Extract, Cyclodextrin, Squalane, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Melia Azadirachta Leaf Extract, Hydroxypropyl Methylcellulose, Sodium Hyaluronate, Tetrahexyldecyl Ascorbate, Rubus Chamaemorus (Cloudberry) Seed Oil, Alumina, Isostearic Acid, Lecithin, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Stearic Acid, Pentylene Glycol, Retinal, Moringa Oleifera Seed Oil, Sodium Polyaspartate, Climbazole, Disodium EDTA, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, Daucus Carota Sativa (Carrot) Seed Oil, Ethylhexylglycerin, 3-O-Ethyl Ascorbic Acid, Dipteryx Odorata (Tonka) Bean Extract, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Vanilla Planifolia (Vanilla) Fruit Extract, Decylene Glycol, 1,2-Hexanediol, BHT, Coumarin

Read enough? Find it on amazon.com

We don't make or sell skincare of our own. So there's nothing here we're trying to push, just an honest read of whether this formula suits your skin.

Compare it with…

All 15 comparisons

Common questions

Is Medik8 Crystal Retinal 6 good for dry skin?

By our read of the formula, it suits dry, dehydrated, normal skin. Medik8 Crystal Retinal 6 is a serum built around Glycerin, Retinal and Squalane. It leans strongest on hydration, barrier repair, brightening / tone. Best suited to dry, dehydrated and normal skin. One caveat: it's best skipped during pregnancy.

How do you use Medik8 Crystal Retinal 6?

Night only. Start 2–3 nights a week and build up as your skin adjusts, and always wear sunscreen the next morning, because retinoids make skin more sun-sensitive.

What are the key ingredients in Medik8 Crystal Retinal 6?

The actives that do the work are Glycerin, Retinal, Squalane, Hyaluronic acid, THD Ascorbate, Caprylic/Capric Triglyceride. The rest of the list is texture, preservatives and emulsifiers that hold the formula together.

Is Medik8 Crystal Retinal 6 safe during pregnancy?

Avoid in pregnancy: Retinal. When in doubt, check with your doctor before using it.

What the 3D scene shows

The scene shows Medik8 Crystal Retinal 6 beside a cross-section of skin, with 3 of its ingredients drawn at the layer each one acts on and at one shared molecular scale: Glycerin and Squalane in the stratum corneum, the dead outer layer where most skincare works; Retinal in the living epidermis, among the cells that are still dividing. Depths come from the same sourced layer data as the rest of this site, and any ingredient whose layer is not established is left out rather than guessed.

Medik8 prints: 0.06% retinal. Read on the brand's own product page, 2026-08-10.

Chemical structure of Glycerin
Building the scene…

This is skin, in section.

The molecules floating inside it are from this bottle, each at the layer it works on, drawn to one true scale. Drag to turn, pinch or scroll to zoom, tap a molecule for its evidence.

Skin in section· molecules from this formula · one true scale
tap it to decode ↻
Crystal Retinal 6Medik8 · Serum · ~€86

Retinal is the reason to consider this serum, with THD Ascorbate behind it.

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