Differin Adapalene Gel 0.1%

Serum~€17typical, July 2026

Our read, in one look

Adapalene is the reason to consider this serum.

The case for it

  • Adapalene, moderate evidence for oil and breakouts
  • No fragrance, alcohol or silicones

Mind this

  • Avoid in pregnancy: Adapalene
  • Evenings only, sunscreen the next morning
  • Add it on its own for a week or two, so you know what your skin is answering to
Best for acne prone, oily skinFind it on amazon.com
Maya's read

Differin Adapalene Gel 0.1% is a serum built around Adapalene. It leans strongest on oil-control & blemishes, anti-aging. Best suited to acne prone and oily skin. One caveat: it's best skipped during pregnancy.

Skip it if you're pregnant or breastfeeding: it contains adapalene, best paused until after.

What it delivers

Hydration6
Barrier repair1
Brightening / tone2
Oil-control & blemishes10
Anti-aging7

How it feels A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. (estimated from the formula)

What's in it that matters

The molecule doing the workAdapaleneHero Active · moderate evidence

Synthetic retinoid optimized for acne with strong comedolytic and anti-inflammatory activity and generally better tolerability than tretinoin.

How to use it

Night only. Start 2–3 nights a week and build up as your skin adjusts, and always wear sunscreen the next morning, because retinoids make skin more sun-sensitive.

Keep it away from

  • Exfoliating acids (AHA / BHA)
  • Benzoyl peroxide
  • Strong vitamin C (L-ascorbic acid)
Not sure about two things on your shelf? Check them →

Against the average serum

HydrationBarrier repairBrighteningOil-controlAnti-aging
This productMedian serum (29 in catalogue)

It scores higher than the median serum on oil control.

It gives up ground on barrier repair, hydration and brightening.

A median, not an average: one unusual formula should not move the middle. The numbers are the same 0 to 10 reads the comparison pages use.

The full ingredients list, decoded

Every ingredient on the label, in the order it appears (highest amount first). We link the 5 our library knows, name what each one does, and flag anything that can irritate or clog. The rest we leave plain, nothing is hidden.

All 8 ingredients, decoded
  1. AdapaleneDrug active
    pregnancy: avoidmild irritant
  2. Carbomer 940Thickener
  3. Edetate Disodium
  4. MethylparabenPreservative
  5. Poloxamer 182
  6. mild irritant
  7. WaterSolvent (base)
  8. Sodium HydroxidePh adjuster
    mild irritant
Copy the raw INCI list

Adapalene, Carbomer 940, Edetate Disodium, Methylparaben, Poloxamer 182, Propylene Glycol, Water, Sodium Hydroxide

Worried about clogged pores specifically? The pore-clogging checker reads this same list against the published comedogenic ratings.

Read enough? Find it on amazon.com

We don't make or sell skincare of our own. So there's nothing here we're trying to push, just an honest read of whether this formula suits your skin.

Compare it with…

All 25 comparisons

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Common questions

Is Differin Adapalene Gel 0.1% good for acne prone skin?

By our read of the formula, it suits acne prone, oily skin. Differin Adapalene Gel 0.1% is a serum built around Adapalene. It leans strongest on oil-control & blemishes, anti-aging. Best suited to acne prone and oily skin. One caveat: it's best skipped during pregnancy.

How do you use Differin Adapalene Gel 0.1%?

Night only. Start 2–3 nights a week and build up as your skin adjusts, and always wear sunscreen the next morning, because retinoids make skin more sun-sensitive.

What are the key ingredients in Differin Adapalene Gel 0.1%?

The actives that do the work are Adapalene. The rest of the list is texture, preservatives and emulsifiers that hold the formula together.

Is Differin Adapalene Gel 0.1% safe during pregnancy?

Avoid in pregnancy: Adapalene. When in doubt, check with your doctor before using it.

Differin Adapalene Gel 0.1%