Head to head
Differin Adapalene Gel 0.1% vs La Roche-Posay Hyalu B5 Suractivated Serum
Same comparison whichever way you searched it: La Roche-Posay Hyalu B5 Suractivated Serum vs Differin Adapalene Gel 0.1%.
The bottom lineDifferin Adapalene Gel 0.1% and La Roche-Posay Hyalu B5 Suractivated Serum are close on what they deliver, so it comes down to your skin: Differin Adapalene Gel 0.1% is the kinder pick for sensitive or reactive skin since it is fragrance-free.
La Roche-Posay Hyalu B5 Suractivated Serum keeps clear of pregnancy-flagged actives, while Differin Adapalene Gel 0.1% carries one that is best paused in pregnancy.
La Roche-PosayHyalu B5 Suractivated SerumSee every ingredient in Hyalu B5 Suractivated Serum, decodedWhich should you pick?
Pick Adapalene Gel 0.1% if
- you are dealing with breakouts and oiliness
- your skin is sensitive or reacts to fragrance
- you want the more affordable option
Pick Hyalu B5 Suractivated Serum if
- your barrier feels stressed and needs the support
- plump, lasting hydration is what you want
- you are pregnant or breastfeeding
What each delivers
Side by side
| Adapalene Gel 0.1% | Hyalu B5 Suractivated Serum | |
|---|---|---|
| Type | Serum | Serum |
| Key actives | Adapalene | Glycerin, Pro-vitamin B5, Hyaluronic acid |
| Texture | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. | A light, fast-absorbing texture that layers cleanly under the rest of your routine, with no greasy film. |
| Fragrance | None detected | Contains fragrance |
| Fungal-acne safe | Likely | Not likely |
| Pregnancy | One caution | No flagged actives |
| Ingredients | 8 listed | 32 listed |
| Price | ~€17 | ~$40 |
What's in one but not the other
Only in Adapalene Gel 0.1%
Both share
No active in common.
Only in Hyalu B5 Suractivated Serum
The molecule doing the work
Better for…
- Fine lines & firmnessEither works
- Breakouts & congestionAdapalene Gel 0.1%
- Dryness & dehydrationHyalu B5 Suractivated Serum
- Sensitive, reactive skinAdapalene Gel 0.1%
Differin Adapalene Gel 0.1% is the cheaper of the two (~€17 vs ~$40).
Ready to pick one?
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Common questions
Is Differin Adapalene Gel 0.1% or La Roche-Posay Hyalu B5 Suractivated Serum better for breakouts & congestion?
For breakouts & congestion, Differin Adapalene Gel 0.1% is the stronger pick by our read of the two formulas. Differin Adapalene Gel 0.1% and La Roche-Posay Hyalu B5 Suractivated Serum are close on what they deliver, so it comes down to your skin: Differin Adapalene Gel 0.1% is the kinder pick for sensitive or reactive skin since it is fragrance-free. La Roche-Posay Hyalu B5 Suractivated Serum keeps clear of pregnancy-flagged actives, while Differin Adapalene Gel 0.1% carries one that is best paused in pregnancy.
Which is cheaper, Differin Adapalene Gel 0.1% or La Roche-Posay Hyalu B5 Suractivated Serum?
Differin Adapalene Gel 0.1% is the cheaper of the two (~€17 vs ~$40).
Can I use Differin Adapalene Gel 0.1% and La Roche-Posay Hyalu B5 Suractivated Serum together?
They are both serums, so you would normally pick one rather than layer both in the same step. You can keep both and alternate them (morning and night, or on different days) if you like variety, but you do not need two.
Compare it with…
All 48 comparisons
- Adapalene Gel 0.1% vs The Ordinary Niacinamide 10% + Zinc 1%
- Adapalene Gel 0.1% vs The Ordinary Hyaluronic Acid 2% + B5 (Original Formulation)
- Adapalene Gel 0.1% vs The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)
- Adapalene Gel 0.1% vs The Ordinary Vitamin C Suspension 23% + HA Spheres 2%
- Adapalene Gel 0.1% vs The Ordinary Retinol 0.5% in Squalane
- Adapalene Gel 0.1% vs CeraVe Resurfacing Retinol Serum
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- Adapalene Gel 0.1% vs Eucerin Anti-Pigment Dual Serum
- Adapalene Gel 0.1% vs The Ordinary Caffeine Solution 5% + EGCG Eye Serum
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- Adapalene Gel 0.1% vs The Ordinary Granactive Retinoid 2% Emulsion
- Adapalene Gel 0.1% vs The Ordinary Granactive Retinoid 5% in Squalane
- Adapalene Gel 0.1% vs Geek & Gorgeous A-Game 10
- Adapalene Gel 0.1% vs Celimax The Vita A Retinal Shot Tightening Booster
- Adapalene Gel 0.1% vs Medicube PDRN Pink Peptide Serum
- Adapalene Gel 0.1% vs Medik8 Liquid Peptides
- Adapalene Gel 0.1% vs Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum
- Adapalene Gel 0.1% vs Beauty of Joseon Glow Deep Serum
- Adapalene Gel 0.1% vs iUNIK Beta Glucan Power Moisture Serum
- Adapalene Gel 0.1% vs Anua Niacinamide 10% + TXA 4% Serum
- Adapalene Gel 0.1% vs The Ordinary GF 15% Solution
- Adapalene Gel 0.1% vs Vichy Minéral 89 Hyaluronic Acid Booster
- Adapalene Gel 0.1% vs CeraVe Skin Renewing Retinol Serum
- Hyalu B5 Suractivated Serum vs The Ordinary Niacinamide 10% + Zinc 1%
- Hyalu B5 Suractivated Serum vs The Ordinary Hyaluronic Acid 2% + B5 (Original Formulation)
- Hyalu B5 Suractivated Serum vs The Ordinary Hyaluronic Acid 2% + B5 (with Ceramides)
- Hyalu B5 Suractivated Serum vs The Ordinary Vitamin C Suspension 23% + HA Spheres 2%
- Hyalu B5 Suractivated Serum vs The Ordinary Retinol 0.5% in Squalane
- Hyalu B5 Suractivated Serum vs CeraVe Resurfacing Retinol Serum
- Hyalu B5 Suractivated Serum vs The Ordinary Azelaic Acid Suspension 10%
- Hyalu B5 Suractivated Serum vs Eucerin Anti-Pigment Dual Serum
- Hyalu B5 Suractivated Serum vs The Ordinary Caffeine Solution 5% + EGCG Eye Serum
- Hyalu B5 Suractivated Serum vs The Ordinary Multi-Peptide + HA Serum
- Hyalu B5 Suractivated Serum vs Medik8 Crystal Retinal 6
- Hyalu B5 Suractivated Serum vs The Ordinary Granactive Retinoid 2% Emulsion
- Hyalu B5 Suractivated Serum vs The Ordinary Granactive Retinoid 5% in Squalane
- Hyalu B5 Suractivated Serum vs Geek & Gorgeous A-Game 10
- Hyalu B5 Suractivated Serum vs Celimax The Vita A Retinal Shot Tightening Booster
- Hyalu B5 Suractivated Serum vs Medicube PDRN Pink Peptide Serum
- Hyalu B5 Suractivated Serum vs Medik8 Liquid Peptides
- Hyalu B5 Suractivated Serum vs Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum
- Hyalu B5 Suractivated Serum vs Beauty of Joseon Glow Deep Serum
- Hyalu B5 Suractivated Serum vs iUNIK Beta Glucan Power Moisture Serum
- Hyalu B5 Suractivated Serum vs Anua Niacinamide 10% + TXA 4% Serum
- Hyalu B5 Suractivated Serum vs The Ordinary GF 15% Solution
- Hyalu B5 Suractivated Serum vs Vichy Minéral 89 Hyaluronic Acid Booster
- Hyalu B5 Suractivated Serum vs CeraVe Skin Renewing Retinol Serum